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Low-dose allopurinol plus azathioprine/ cyclosporin/prednisolone, a novel immunosuppressive regimen

Overview of attention for article published in The Lancet, July 1993
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Title
Low-dose allopurinol plus azathioprine/ cyclosporin/prednisolone, a novel immunosuppressive regimen
Published in
The Lancet, July 1993
DOI 10.1016/0140-6736(93)91287-v
Pubmed ID
Authors

P. Chocair, L. Ianhez, S. Arap, E. Sabbaga, J. Duley, H.A. Simmonds, J.S. Cameron

Abstract

Early rejection can still complicate renal transplantation even with cyclosporin. We added low-dose allopurinol (25 mg on alternative days) to "triple" immunosuppression with cyclosporin, prednisolone, and azathioprine for twelve recipients of cadaver renal grafts. The controls were fifteen patients on triple therapy alone. Only one rejection episode occurred among the allopurinol-treated patients, whereas eleven controls had rejections (seven with more than one episode). Allopurinol may be toxic when combined with azathioprine, yet the bone marrow tolerated the new regimen well. As expected, reduction of the azathioprine dose was necessary in the treated group.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 20%
Student > Ph. D. Student 3 15%
Professor 2 10%
Student > Postgraduate 2 10%
Student > Master 1 5%
Other 3 15%
Unknown 5 25%
Readers by discipline Count As %
Medicine and Dentistry 9 45%
Biochemistry, Genetics and Molecular Biology 3 15%
Immunology and Microbiology 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Unknown 6 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2015.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from The Lancet
#25,991
of 42,669 outputs
Outputs of similar age
#5,765
of 18,765 outputs
Outputs of similar age from The Lancet
#48
of 108 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 42,669 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 67.9. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 18,765 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.