| Title |
Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives
|
|---|---|
| Published in |
Molecular Neurobiology, March 2011
|
| DOI | 10.1007/s12035-011-8175-3 |
| Pubmed ID | |
| Authors |
Anne Matthys, Guy Haegeman, Kathleen Van Craenenbroeck, Peter Vanhoenacker |
| Abstract |
Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser extent, agonists, however, are quite contradictory. In this review, we not only discuss in detail the role of the 5-HT7 receptor in the CNS but also propose some hypothetical models, which could explain the observed inconsistencies. These models are based on two novel concepts within the field of G protein-coupled receptors (GPCR), namely biphasic signaling and G protein-independent signaling, which both have been shown to be mediated by GPCR dimerization. This led us to suggest that the 5-HT7 receptor could reside in different dimeric contexts and initiate different signaling pathways, depending on the neuronal circuitry and/or brain region. In conclusion, we highlight GPCR dimerization and G protein-independent signaling as two promising future directions in 5-HT7 receptor research, which ultimately might lead to the development of more efficient dimer- and/or pathway-specific therapeutics. |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 2 | 1% |
| Poland | 2 | 1% |
| Malta | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 131 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 20% |
| Researcher | 20 | 14% |
| Student > Master | 19 | 13% |
| Student > Bachelor | 13 | 9% |
| Professor | 6 | 4% |
| Other | 24 | 17% |
| Unknown | 31 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 24% |
| Medicine and Dentistry | 20 | 14% |
| Neuroscience | 20 | 14% |
| Chemistry | 12 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 8% |
| Other | 14 | 10% |
| Unknown | 30 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2023.
All research outputs
#2,528,311
of 23,275,636 outputs
Outputs from Molecular Neurobiology
#307
of 3,528 outputs
Outputs of similar age
#11,223
of 109,852 outputs
Outputs of similar age from Molecular Neurobiology
#4
of 8 outputs
Altmetric has tracked 23,275,636 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,528 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,852 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.