| Title |
HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing
|
|---|---|
| Published in |
Diabetologia, January 2018
|
| DOI | 10.1007/s00125-017-4541-7 |
| Pubmed ID | |
| Authors |
Fanfan Zheng, Li Yan, Zhenchun Yang, Baoliang Zhong, Wuxiang Xie |
| Abstract |
The aim of the study was to evaluate longitudinal associations between HbA1c levels, diabetes status and subsequent cognitive decline over a 10 year follow-up period. Data from wave 2 (2004-2005) to wave 7 (2014-2015) of the English Longitudinal Study of Ageing (ELSA) were analysed. Cognitive function was assessed at baseline (wave 2) and reassessed every 2 years at waves 3-7. Linear mixed models were used to evaluate longitudinal associations. The study comprised 5189 participants (55.1% women, mean age 65.6 ± 9.4 years) with baseline HbA1c levels ranging from 15.9 to 126.3 mmol/mol (3.6-13.7%). The mean follow-up duration was 8.1 ± 2.8 years and the mean number of cognitive assessments was 4.9 ± 1.5. A 1 mmol/mol increment in HbA1c was significantly associated with an increased rate of decline in global cognitive z scores (-0.0009 SD/year, 95% CI -0.0014, -0.0003), memory z scores (-0.0005 SD/year, 95% CI -0.0009, -0.0001) and executive function z scores (-0.0008 SD/year, 95% CI -0.0013, -0.0004) after adjustment for baseline age, sex, total cholesterol, HDL-cholesterol, triacylglycerol, high-sensitivity C-reactive protein, BMI, education, marital status, depressive symptoms, current smoking, alcohol consumption, hypertension, CHD, stroke, chronic lung disease and cancer. Compared with participants with normoglycaemia, the multivariable-adjusted rate of global cognitive decline associated with prediabetes and diabetes was increased by -0.012 SD/year (95% CI -0.022, -0.002) and -0.031 SD/year (95% CI -0.046, -0.015), respectively (p for trend <0.001). Similarly, memory, executive function and orientation z scores showed an increased rate of cognitive decline with diabetes. Significant longitudinal associations between HbA1c levels, diabetes status and long-term cognitive decline were observed in this study. Future studies are required to determine the effects of maintaining optimal glucose control on the rate of cognitive decline in people with diabetes. |
X Demographics
The data shown below were collected from the profiles of 479 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 79 | 16% |
| United States | 73 | 15% |
| Spain | 30 | 6% |
| Canada | 16 | 3% |
| Mexico | 11 | 2% |
| Australia | 10 | 2% |
| France | 10 | 2% |
| Netherlands | 9 | 2% |
| Argentina | 8 | 2% |
| Other | 74 | 15% |
| Unknown | 159 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 361 | 75% |
| Practitioners (doctors, other healthcare professionals) | 72 | 15% |
| Scientists | 44 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 292 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 38 | 13% |
| Researcher | 34 | 12% |
| Student > Master | 28 | 10% |
| Student > Ph. D. Student | 25 | 9% |
| Student > Doctoral Student | 19 | 7% |
| Other | 49 | 17% |
| Unknown | 99 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 21% |
| Psychology | 27 | 9% |
| Nursing and Health Professions | 24 | 8% |
| Biochemistry, Genetics and Molecular Biology | 13 | 4% |
| Neuroscience | 13 | 4% |
| Other | 43 | 15% |
| Unknown | 110 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1287. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2024.
All research outputs
#10,548
of 25,732,188 outputs
Outputs from Diabetologia
#7
of 5,376 outputs
Outputs of similar age
#176
of 452,662 outputs
Outputs of similar age from Diabetologia
#1
of 66 outputs
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