Title |
Eosinophils: Biological Properties and Role in Health and Disease
|
---|---|
Published in |
Clinical & Experimental Allergy, April 2008
|
DOI | 10.1111/j.1365-2222.2008.02958.x |
Pubmed ID | |
Authors |
Simon P Hogan, Helene F Rosenberg, Redwan Moqbel, Simon Phipps, Paul S Foster, Paige Lacy, A Barry Kay, Marc E Rothenberg |
Abstract |
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. In this review, the biology of eosinophils is summarized, focusing on transcriptional regulation of eosinophil differentiation, characterization of the growing properties of eosinophil granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of eosinophil degranulation. New views on the role of eosinophils in homeostatic function are examined, including developmental biology and innate and adaptive immunity (as well as their interaction with mast cells and T cells) and their proposed role in disease processes including infections, asthma, and gastrointestinal disorders. Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | <1% |
Spain | 3 | <1% |
Germany | 1 | <1% |
Sweden | 1 | <1% |
Norway | 1 | <1% |
Korea, Republic of | 1 | <1% |
United States | 1 | <1% |
Unknown | 417 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 68 | 16% |
Student > Ph. D. Student | 66 | 15% |
Student > Master | 59 | 14% |
Student > Bachelor | 59 | 14% |
Student > Doctoral Student | 24 | 6% |
Other | 69 | 16% |
Unknown | 84 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 98 | 23% |
Medicine and Dentistry | 94 | 22% |
Biochemistry, Genetics and Molecular Biology | 50 | 12% |
Immunology and Microbiology | 41 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
Other | 36 | 8% |
Unknown | 99 | 23% |