| Title |
A structural view of translation initiation in bacteria
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2008
|
| DOI | 10.1007/s00018-008-8416-4 |
| Pubmed ID | |
| Authors |
A. Simonetti, S. Marzi, L. Jenner, A. Myasnikov, P. Romby, G. Yusupova, B. P. Klaholz, M. Yusupov |
| Abstract |
The assembly of the protein synthesis machinery occurs during translation initiation. In bacteria, this process involves the binding of messenger RNA(mRNA) start site and fMet-tRNA(fMet) to the ribosome, which results in the formation of the first codon-anticodon interaction and sets the reading frame for the decoding of the mRNA. This interaction takes place in the peptidyl site of the 30S ribosomal subunit and is controlled by the initiation factors IF1, IF2 and IF3 to form the 30S initiation complex. The binding of the 50S subunit and the ejection of the IFs mark the irreversible transition to the elongation phase. Visualization of these ligands on the ribosome has been achieved by cryo-electron microscopy and X-ray crystallography studies, which has helped to understand the mechanism of translation initiation at the molecular level. Conformational changes associated with different functional states provide a dynamic view of the initiation process and of its regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| United States | 3 | 1% |
| Estonia | 3 | 1% |
| United Kingdom | 3 | 1% |
| Belgium | 2 | <1% |
| India | 1 | <1% |
| Israel | 1 | <1% |
| Austria | 1 | <1% |
| Italy | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 234 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 27% |
| Researcher | 55 | 22% |
| Student > Master | 35 | 14% |
| Student > Bachelor | 25 | 10% |
| Student > Doctoral Student | 11 | 4% |
| Other | 26 | 10% |
| Unknown | 33 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 112 | 44% |
| Biochemistry, Genetics and Molecular Biology | 73 | 29% |
| Chemistry | 12 | 5% |
| Engineering | 5 | 2% |
| Medicine and Dentistry | 4 | 2% |
| Other | 12 | 5% |
| Unknown | 36 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2023.
All research outputs
#7,591,533
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,602
of 4,151 outputs
Outputs of similar age
#48,253
of 170,503 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#18
of 38 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.