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X Demographics
Mendeley readers
Attention Score in Context
| Title |
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
|
|---|---|
| Published in |
Nature Communications, January 2018
|
| DOI | 10.1038/s41467-017-02697-5 |
| Pubmed ID | |
| Authors |
Ake T. Lu, Luting Xue, Elias L. Salfati, Brian H. Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M. Murabito, Douglas P. Kiel, Pei-Chien Tsai, Idil Yet, Jordana T. Bell, Massimo Mangino, Toshiko Tanaka, Allan F. McRae, Riccardo E. Marioni, Peter M. Visscher, Naomi R. Wray, Ian J. Deary, Morgan E. Levine, Austin Quach, Themistocles Assimes, Philip S. Tsao, Devin Absher, James D. Stewart, Yun Li, Alex P. Reiner, Lifang Hou, Andrea A. Baccarelli, Eric A. Whitsel, Abraham Aviv, Alexia Cardona, Felix R. Day, Nicholas J. Wareham, John R. B. Perry, Ken K. Ong, Kenneth Raj, Kathryn L. Lunetta, Steve Horvath |
| Abstract |
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration (EEAA). Mendelian randomization analysis suggests causal influences of menarche and menopause on IEAA and lipoproteins on IEAA and EEAA. Variants associated with longer leukocyte telomere length (LTL) in the telomerase reverse transcriptase gene (TERT) paradoxically confer higher IEAA (P < 2.7 × 10-11). Causal modeling indicates TERT-specific and independent effects on LTL and IEAA. Experimental hTERT-expression in primary human fibroblasts engenders a linear increase in DNA methylation age with cell population doubling number. Together, these findings indicate a critical role for hTERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication-dependent telomere shortening. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 23% |
| United Kingdom | 6 | 14% |
| Canada | 2 | 5% |
| Germany | 2 | 5% |
| France | 2 | 5% |
| India | 1 | 2% |
| Russia | 1 | 2% |
| China | 1 | 2% |
| Spain | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 16 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 57% |
| Scientists | 18 | 41% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 303 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 19% |
| Researcher | 58 | 19% |
| Student > Master | 26 | 9% |
| Student > Bachelor | 24 | 8% |
| Other | 18 | 6% |
| Other | 48 | 16% |
| Unknown | 71 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 87 | 29% |
| Agricultural and Biological Sciences | 38 | 13% |
| Medicine and Dentistry | 32 | 11% |
| Neuroscience | 13 | 4% |
| Psychology | 6 | 2% |
| Other | 38 | 13% |
| Unknown | 89 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2024.
All research outputs
#360,442
of 25,368,786 outputs
Outputs from Nature Communications
#5,660
of 56,810 outputs
Outputs of similar age
#8,411
of 449,573 outputs
Outputs of similar age from Nature Communications
#133
of 1,205 outputs
Altmetric has tracked 25,368,786 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,810 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,573 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,205 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.