| Title |
IDH1 and IDH2 Mutations in Gliomas
|
|---|---|
| Published in |
Current Neurology and Neuroscience Reports, March 2013
|
| DOI | 10.1007/s11910-013-0345-4 |
| Pubmed ID | |
| Authors |
Adam L. Cohen, Sheri L. Holmen, Howard Colman |
| Abstract |
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a possible oncometabolite, and to not produce NADPH. IDH mutations are oncogenic, although whether the mechanism is through alterations in hydroxylases, redox potential, cellular metabolism, or gene expression is not clear. The mutations also drive increased methylation in gliomas. Gliomas with mutated IDH1 and IDH2 have improved prognosis compared with gliomas with wild-type IDH. Mutated IDH can now be detected by immunohistochemistry and magnetic resonance spectroscopy. No drugs currently target mutated IDH, although this remains an area of active research. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 10% |
| Saudi Arabia | 2 | 10% |
| Colombia | 1 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| India | 1 | 5% |
| Kuwait | 1 | 5% |
| Turkey | 1 | 5% |
| Brazil | 1 | 5% |
| Canada | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 9 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 60% |
| Scientists | 4 | 20% |
| Practitioners (doctors, other healthcare professionals) | 3 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,228 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | <1% |
| United Kingdom | 5 | <1% |
| Germany | 3 | <1% |
| Brazil | 3 | <1% |
| Portugal | 2 | <1% |
| Italy | 1 | <1% |
| Sweden | 1 | <1% |
| South Africa | 1 | <1% |
| Finland | 1 | <1% |
| Other | 10 | <1% |
| Unknown | 1193 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 196 | 16% |
| Student > Master | 176 | 14% |
| Researcher | 153 | 12% |
| Student > Bachelor | 150 | 12% |
| Student > Doctoral Student | 94 | 8% |
| Other | 220 | 18% |
| Unknown | 239 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 305 | 25% |
| Biochemistry, Genetics and Molecular Biology | 215 | 18% |
| Agricultural and Biological Sciences | 186 | 15% |
| Neuroscience | 65 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 34 | 3% |
| Other | 137 | 11% |
| Unknown | 286 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#1,163,282
of 25,473,687 outputs
Outputs from Current Neurology and Neuroscience Reports
#42
of 993 outputs
Outputs of similar age
#8,542
of 210,520 outputs
Outputs of similar age from Current Neurology and Neuroscience Reports
#1
of 10 outputs
Altmetric has tracked 25,473,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 993 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done particularly well, scoring higher than 95% of its peers.
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