| Title |
Norepinephrine Homogeneously Inhibits α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) Mediated Currents in All Layers of the Temporal Cortex of the Rat
|
|---|---|
| Published in |
Neurochemical Research, April 2009
|
| DOI | 10.1007/s11064-009-9966-z |
| Pubmed ID | |
| Authors |
Lu Dinh, Tram Nguyen, Humberto Salgado, Marco Atzori |
| Abstract |
The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applications of NE (20 microM) decreased glutamatergic excitatory post-synaptic currents (EPSCs) in all cortical layers. Changes in the kinetics of synaptic EPSCs, invariance of pair pulse ratio and of the coefficient-of-variation, together with the decrease of responses to pressure-application of AMPA (500 microM), indicated the postsynaptic nature of the adrenergic effect. Pharmacological experiments suggested that the NE-induced depression of EPSCs is caused by the activation of alpha1 adrenoceptors, PLC, and a Ca(2+)-independent PKC. We speculate that the decrease in temporal cortex excitability might promote a posterior-to-anterior shift in cortical activation together with a decrease in spontaneous background activity, resulting eventually in more effective sensory processing. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Mexico | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 64 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 21% |
| Researcher | 13 | 19% |
| Student > Master | 7 | 10% |
| Student > Bachelor | 5 | 7% |
| Professor | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 16 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 30% |
| Neuroscience | 9 | 13% |
| Medicine and Dentistry | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Psychology | 2 | 3% |
| Other | 8 | 12% |
| Unknown | 19 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2022.
All research outputs
#7,687,335
of 23,390,392 outputs
Outputs from Neurochemical Research
#603
of 2,131 outputs
Outputs of similar age
#33,597
of 94,884 outputs
Outputs of similar age from Neurochemical Research
#5
of 12 outputs
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