| Title |
Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression
|
|---|---|
| Published in |
Targeted Oncology, January 2018
|
| DOI | 10.1007/s11523-018-0551-8 |
| Pubmed ID | |
| Authors |
Marzia Pucci, Pablo Reclusa Asiáin, Elena Duréndez Sáez, Eloisa Jantus-Lewintre, Mahafarin Malarani, Shahanavaj Khan, Simona Fontana, Aung Naing, Francesco Passiglia, Luis E. Raez, Christian Rolfo, Simona Taverna |
| Abstract |
Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 18% |
| Norway | 1 | 9% |
| Ireland | 1 | 9% |
| Switzerland | 1 | 9% |
| United States | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 45% |
| Members of the public | 4 | 36% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 15% |
| Researcher | 5 | 9% |
| Student > Bachelor | 4 | 7% |
| Professor | 2 | 4% |
| Professor > Associate Professor | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 28 | 52% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 28% |
| Medicine and Dentistry | 6 | 11% |
| Chemical Engineering | 1 | 2% |
| Sports and Recreations | 1 | 2% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 28 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2018.
All research outputs
#5,714,442
of 23,018,998 outputs
Outputs from Targeted Oncology
#71
of 555 outputs
Outputs of similar age
#114,891
of 440,577 outputs
Outputs of similar age from Targeted Oncology
#2
of 13 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 555 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,577 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.