| Title |
Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, February 2005
|
| DOI | 10.1007/s00253-004-1802-4 |
| Pubmed ID | |
| Authors |
Espen Fjærvik, Sergey B. Zotchev |
| Abstract |
The polyene macrolide antibiotic nystatin, produced commercially by the bacterium Streptomyces noursei, is an important antifungal agent used in human therapy for treatment of certain types of mycoses. Early studies on nystatin biosynthesis in S. noursei provided important information regarding the precursors utilised in nystatin biosynthesis and factors affecting antibiotic yield. New insights into the enzymology of nystatin synthesis became available after the gene cluster governing nystatin biosynthesis in S. noursei was cloned and analysed. Six large polyketide synthase proteins were implicated in the formation of the nystatin macrolactone ring, while other enzymes, such as P450 monooxygenases and glycosyltransferase, were assumed responsible for ring "decoration". The latter data, supported by analysis of the polyene mixture synthesised by the nystatin producer, helped elucidate the complete nystatin biosynthetic pathway. This information has proved useful for engineered biosynthesis of novel nystatin analogues, suggesting a plausible route for the generation of potentially safer and more efficient antifungal drugs. |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| France | 1 | <1% |
| Unknown | 127 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 22% |
| Student > Bachelor | 23 | 18% |
| Student > Master | 16 | 12% |
| Researcher | 12 | 9% |
| Student > Doctoral Student | 6 | 5% |
| Other | 12 | 9% |
| Unknown | 32 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 24% |
| Biochemistry, Genetics and Molecular Biology | 21 | 16% |
| Chemistry | 19 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
| Immunology and Microbiology | 5 | 4% |
| Other | 10 | 8% |
| Unknown | 35 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2023.
All research outputs
#8,022,830
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#2,748
of 8,034 outputs
Outputs of similar age
#38,252
of 146,474 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#33
of 57 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,034 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.