| Title |
What’s new in the renin-angiotensin system?
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2004
|
| DOI | 10.1007/s00018-004-4246-1 |
| Pubmed ID | |
| Authors |
S. Y. Chai, R. Fernando, G. Peck, S. -Y. Ye, F. A. O. Mendelsohn, T. A. Jenkins, A. L. Albiston |
| Abstract |
The angiotensin AT(4) receptor was originally defined as the specific, high-affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor. Central administration of Ang IV, its analogues or LVV-hemorphin 7 markedly enhance learning and memory in normal rodents and reverse memory deficits observed in animal models of amnesia. The AT(4) receptor has a broad distribution and is found in a range of tissues, including the adrenal gland, kidney, lung and heart. In the kidney Ang IV increases renal cortical blood flow and decreases Na(+) transport in isolated renal proximal tubules. The AT(4) receptor has recently been identified as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). IRAP is a type II integral membrane spanning protein belonging to the M1 family of aminopeptidases and is predominantly found in GLUT4 vesicles in insulin-responsive cells. Three hypotheses for the memory-potentiating effects of the AT(4) receptor/IRAP ligands, Ang IV and LVV-hemorphin 7, are proposed: (i) acting as potent inhibitors of IRAP, they may prolong the action of endogenous promnestic peptides; (ii) they may modulate glucose uptake by modulating trafficking of GLUT4; (iii) IRAP may act as a receptor, transducing the signal initiated by ligand binding to its C-terminal domain to the intracellular domain that interacts with several cytoplasmic proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 97 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 20% |
| Researcher | 18 | 18% |
| Student > Bachelor | 14 | 14% |
| Student > Master | 13 | 13% |
| Student > Postgraduate | 7 | 7% |
| Other | 17 | 17% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 22% |
| Medicine and Dentistry | 18 | 18% |
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 10% |
| Neuroscience | 8 | 8% |
| Other | 12 | 12% |
| Unknown | 18 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2023.
All research outputs
#8,759,452
of 25,837,817 outputs
Outputs from Cellular and Molecular Life Sciences
#2,227
of 5,993 outputs
Outputs of similar age
#25,305
of 75,877 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 32 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,993 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
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We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.