| Title |
Neurogenesis and schizophrenia: dividing neurons in a divided mind?
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, April 2007
|
| DOI | 10.1007/s00406-007-0733-3 |
| Pubmed ID | |
| Authors |
Andreas Reif, Angelika Schmitt, Sabrina Fritzen, Klaus-Peter Lesch |
| Abstract |
Forty years after the initial discovery of neurogenesis in the postnatal brain of the rat, convincing evidence has been accrued that functional neurons are generated throughout the entire lifespan, particularly in the dentate gyrus (DG) and the subventricular zone (SVZ). This phenomenon has been termed adult neurogenesis (AN) and while it was detected in all examined mammalian species including humans, the physiological role of this process remains unknown. Although a plethora of animal studies indicate an involvement of AN in the pathophysiology of depression, this view has recently kindled considerable controversy. Pertinent studies in humans failed to confirm a role of reduced hippocampal neural stem cell proliferation (NSP) in depression but suggest a contribution to the pathophysiology of schizophrenia. The functional relevance of disturbed AN may encompass erroneous temporal encoding of new memory traces, thereby contributing to cognitive deficits observed in schizophrenia. This AN-hypothesis of schizophrenia is supported by neuroimaging, as well as by several genetically modified rodent models, e.g. reelin and NPAS3 knockout mice. Furthermore, several genes impacting on AN, including NPAS3, were also found to be associated with schizophrenia by case-control studies. In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 2% |
| United States | 2 | 1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 153 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 17% |
| Student > Ph. D. Student | 25 | 16% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 19 | 12% |
| Professor > Associate Professor | 10 | 6% |
| Other | 29 | 18% |
| Unknown | 30 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 24% |
| Neuroscience | 26 | 16% |
| Medicine and Dentistry | 22 | 14% |
| Psychology | 18 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Other | 9 | 6% |
| Unknown | 39 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2015.
All research outputs
#7,856,604
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#462
of 1,243 outputs
Outputs of similar age
#26,217
of 73,568 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#5
of 7 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.