| Title |
Heat-shock protein 90, a chaperone for folding and regulation
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2002
|
| DOI | 10.1007/pl00012491 |
| Pubmed ID | |
| Authors |
D. Picard |
| Abstract |
Heat-shock protein 90 (Hsp90) is an abundant and highly conserved molecular chaperone that is essential for viability in eukaryotes. Hsp90 fulfills a housekeeping function in contributing to the folding, maintenance of structural integrity and proper regulation of a subset of cytosolic proteins. A remarkable proportion of its substrates are proteins involved in cell cycle control and signal transduction. Hsp90 acts with a cohort of Hsp90 co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. The large conformational flexibility of Hsp90 and a multitude of dynamic co-chaperone complexes contribute to generating functional diversity, and allow Hsp90 to assist a wide range of substrates. |
Mendeley readers
The data shown below were compiled from readership statistics for 256 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| United States | 3 | 1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| Portugal | 1 | <1% |
| Belgium | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 243 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 21% |
| Researcher | 37 | 14% |
| Student > Master | 34 | 13% |
| Student > Bachelor | 31 | 12% |
| Student > Doctoral Student | 17 | 7% |
| Other | 32 | 13% |
| Unknown | 52 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 80 | 31% |
| Biochemistry, Genetics and Molecular Biology | 63 | 25% |
| Medicine and Dentistry | 15 | 6% |
| Neuroscience | 12 | 5% |
| Chemistry | 10 | 4% |
| Other | 22 | 9% |
| Unknown | 54 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2024.
All research outputs
#3,799,086
of 25,374,917 outputs
Outputs from Cellular and Molecular Life Sciences
#713
of 5,877 outputs
Outputs of similar age
#4,978
of 49,680 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 17 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 49,680 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.