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Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling ▿ †

Overview of attention for article published in Journal of Virology, August 2010
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

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2 patents
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1 Wikipedia page

Citations

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206 Dimensions

Readers on

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260 Mendeley
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Title
Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling ▿ †
Published in
Journal of Virology, August 2010
DOI 10.1128/jvi.00949-10
Pubmed ID
Authors

Jelke J. Fros, Wen Jun Liu, Natalie A. Prow, Corinne Geertsema, Maarten Ligtenberg, Dana L. Vanlandingham, Esther Schnettler, Just M. Vlak, Andreas Suhrbier, Alexander A. Khromykh, Gorben P. Pijlman

Abstract

Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon (IFN). Recent research, however, suggests that alphaviruses may have additional mechanisms to circumvent the host's antiviral IFN response. Here we show that CHIKV replication is resistant to inhibition by interferon once RNA replication has been established and that CHIKV actively suppresses the antiviral IFN response by preventing IFN-induced gene expression. Both CHIKV infection and CHIKV replicon RNA replication efficiently blocked STAT1 phosphorylation and/or nuclear translocation in mammalian cells induced by either type I or type II IFN. Expression of individual CHIKV nonstructural proteins (nsPs) showed that nsP2 was a potent inhibitor of IFN-induced JAK-STAT signaling. In addition, mutations in CHIKV-nsP2 (P718S) and Sindbis virus (SINV)-nsP2 (P726S) that render alphavirus replicons noncytopathic significantly reduced JAK-STAT inhibition. This host shutoff-independent inhibition of IFN signaling by CHIKV is likely to have an important role in viral pathogenesis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 260 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
United Kingdom 1 <1%
Thailand 1 <1%
Unknown 255 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 68 26%
Student > Bachelor 37 14%
Student > Master 32 12%
Researcher 26 10%
Student > Doctoral Student 15 6%
Other 36 14%
Unknown 46 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 79 30%
Biochemistry, Genetics and Molecular Biology 53 20%
Immunology and Microbiology 44 17%
Medicine and Dentistry 11 4%
Chemistry 8 3%
Other 13 5%
Unknown 52 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#5,446,629
of 25,373,627 outputs
Outputs from Journal of Virology
#5,588
of 25,691 outputs
Outputs of similar age
#22,402
of 104,060 outputs
Outputs of similar age from Journal of Virology
#57
of 169 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,691 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,060 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.