Title |
Experience-dependent structural synaptic plasticity in the mammalian brain
|
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Published in |
Nature Reviews Neuroscience, September 2009
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DOI | 10.1038/nrn2699 |
Pubmed ID | |
Authors |
Anthony Holtmaat, Karel Svoboda |
Abstract |
Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal and injured adult brain. Although the overall cell-specific morphology of axons and dendrites, as well as of a subpopulation of small synaptic structures, are remarkably stable, there is increasing evidence that experience-dependent plasticity of specific circuits in the somatosensory and visual cortex involves cell type-specific structural plasticity: some boutons and dendritic spines appear and disappear, accompanied by synapse formation and elimination, respectively. This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
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Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 26 | 1% |
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France | 7 | <1% |
Switzerland | 6 | <1% |
Italy | 4 | <1% |
Spain | 4 | <1% |
Other | 32 | 1% |
Unknown | 2101 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 442 | 20% |
Student > Master | 261 | 12% |
Student > Bachelor | 196 | 9% |
Student > Doctoral Student | 103 | 5% |
Other | 362 | 16% |
Unknown | 265 | 12% |
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Neuroscience | 525 | 23% |
Medicine and Dentistry | 152 | 7% |
Psychology | 143 | 6% |
Biochemistry, Genetics and Molecular Biology | 96 | 4% |
Other | 236 | 11% |
Unknown | 316 | 14% |