| Title |
Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, January 2018
|
| DOI | 10.1007/s10549-017-4610-0 |
| Pubmed ID | |
| Authors |
Anne-Sophie Hamy, Giang-Thanh Lam, Enora Laas, Lauren Darrigues, Thomas Balezeau, Julien Guerin, Alain Livartowski, Benjamin Sadacca, Jean-Yves Pierga, Anne Vincent-Salomon, Florence Coussy, Veronique Becette, Hélène Bonsang-Kitzis, Roman Rouzier, Jean-Guillaume Feron, Gabriel Benchimol, Marick Laé, Fabien Reyal |
| Abstract |
Few studies evaluated the prognostic value of the presence of lymphovascular invasion (LVI) after neoadjuvant chemotherapy (NAC) for breast cancer (BC). The association between LVI and survival was evaluated in a cohort of BC patients treated by NAC between 2002 and 2011. Five post-NAC prognostic scores (ypAJCC, RCB, CPS, CPS + EG and Neo-Bioscore) were evaluated and compared with or without the addition of LVI. Out of 1033 tumors, LVI was present on surgical specimens in 29.2% and absent in 70.8% of the cases. Post-NAC LVI was associated with impaired disease-free survival (DFS) (HR 2.54; 95% CI 1.96-3.31; P < 0.001), and the magnitude of this effect depended on BC subtype (Pinteraction = 0.003), (luminal BC: HR 1.83; P = 0.003; triple negative BC: HR 3.73; P < 0.001; HER2-positive BC: HR 6.21; P < 0.001). Post-NAC LVI was an independent predictor of local relapse, distant metastasis, and overall survival; and increased the accuracy of all five post-NAC prognostic scoring systems. Post-NAC LVI is a strong independent prognostic factor that: (i) should be systematically reported in pathology reports; (ii) should be used as stratification factor after NAC to propose inclusion in second-line trials or adjuvant treatment; (iii) should be included in post-NAC scoring systems. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 6 | 43% |
| United States | 1 | 7% |
| United Kingdom | 1 | 7% |
| Brazil | 1 | 7% |
| Italy | 1 | 7% |
| Belgium | 1 | 7% |
| Unknown | 3 | 21% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 57% |
| Practitioners (doctors, other healthcare professionals) | 4 | 29% |
| Scientists | 2 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 16% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Professor | 3 | 7% |
| Other | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 19 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 30% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Nursing and Health Professions | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Economics, Econometrics and Finance | 2 | 5% |
| Other | 1 | 2% |
| Unknown | 20 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#4,587,258
of 24,396,012 outputs
Outputs from Breast Cancer Research and Treatment
#792
of 4,852 outputs
Outputs of similar age
#97,360
of 449,034 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#20
of 78 outputs
Altmetric has tracked 24,396,012 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,852 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,034 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.