| Title |
Tear fluid levels of MMP-8 are elevated in ocular rosacea—treatment effect of oral doxycycline
|
|---|---|
| Published in |
Graefe's Archive for Clinical and Experimental Ophthalmology, January 2006
|
| DOI | 10.1007/s00417-005-0212-3 |
| Pubmed ID | |
| Authors |
Marko Määttä, Osmo Kari, Taina Tervahartiala, Sirje Peltonen, Marjatta Kari, Matti Saari, Timo Sorsa |
| Abstract |
Ocular rosacea (OcR) is a chronic inflammatory disease especially affecting lid margins. Previous studies have shown that it is accompanied by increased levels and activation of tear fluid gelatinases. Matrix metalloproteinase 8 (MMP-8; collagenase 2) levels and activation are commonly elevated in many inflammatory conditions. Therefore we studied here whether MMP-8 concentration and activation in tear fluid are increased also in OcR, and if an oral doxycycline regimen could rectify the situation. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 38 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 23% |
| Student > Postgraduate | 5 | 13% |
| Researcher | 5 | 13% |
| Student > Doctoral Student | 3 | 8% |
| Student > Ph. D. Student | 3 | 8% |
| Other | 5 | 13% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 41% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Agricultural and Biological Sciences | 3 | 8% |
| Nursing and Health Professions | 2 | 5% |
| Engineering | 2 | 5% |
| Other | 1 | 3% |
| Unknown | 11 | 28% |