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Type I IFN‐β gene therapy suppresses cardiac CD8+ T‐cell infiltration during autoimmune myocarditis

Overview of attention for article published in Immunology & Cell Biology, April 2004
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Mentioned by

patent
1 patent

Citations

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23 Dimensions

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11 Mendeley
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Title
Type I IFN‐β gene therapy suppresses cardiac CD8+ T‐cell infiltration during autoimmune myocarditis
Published in
Immunology & Cell Biology, April 2004
DOI 10.1046/j.0818-9641.2004.01234.x
Pubmed ID
Authors

Emmalene J Bartlett, Jason C Lenzo, Soruba Sivamoorthy, Josephine P Mansfield, Vanessa S Cull, Cassandra M James

Abstract

Gene therapy using DNA encoding type I IFN subtypes IFNA6, IFNA9 and IFNB suppresses murine cytomegalovirus (MCMV)-myocarditis, a predominantly cell-mediated disease in BALB/c mice. CD8(+) T cells are the principal cell type within the inflamed myocardium. As such, we investigated the effects of IFN subtype treatment on this T-cell subset and other cell types in the cardiac infiltrate. In the acute phase of disease, IFNA6 and IFNA9 treatments significantly reduced the number of CD8(+) T cells within the foci of cellular infiltration in the heart. During the chronic phase, which is primarily autoimmune in nature, IFNB treatment significantly reduced CD8(+) T cells. B-cell and neutrophil numbers in the cardiac infiltrate were also reduced following IFNB immunotherapy. Although early inflammatory responses are important for resolution of virus infection, high numbers of lymphocytes persisting in the myocardium may lead to exacerbation of disease. Our data suggests that type I IFN DNA therapy regulates cardiac cellular infiltration. Thus, treatment with IFN-beta administered prophylactically to high-risk patients in acquiring CMV infection may reduce the development of chronic autoimmune myocarditis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 36%
Unspecified 1 9%
Other 1 9%
Student > Ph. D. Student 1 9%
Student > Bachelor 1 9%
Other 2 18%
Unknown 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 27%
Medicine and Dentistry 2 18%
Immunology and Microbiology 2 18%
Computer Science 1 9%
Unspecified 1 9%
Other 0 0%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2018.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Immunology & Cell Biology
#846
of 1,848 outputs
Outputs of similar age
#21,863
of 64,950 outputs
Outputs of similar age from Immunology & Cell Biology
#2
of 6 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,848 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 64,950 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.