| Title |
Biases in ion transmission through an electrospray ionization-mass spectrometry capillary inlet
|
|---|---|
| Published in |
Journal of the American Society for Mass Spectrometry, December 2009
|
| DOI | 10.1016/j.jasms.2009.08.018 |
| Pubmed ID | |
| Authors |
Jason S. Page, Ioan Marginean, Erin S. Baker, Ryan T. Kelly, Keqi Tang, Richard D. Smith |
| Abstract |
A heated capillary inlet for an electrospray ionization mass spectrometry (ESI-MS) interface was compared with shorter versions of the inlet to determine the effects on transmission and ionization efficiencies for low-flow (nano) electrosprays. Five different inlet lengths were studied, ranging from 6.4 to 1.3 cm. As expected, the electrospray current transmission efficiency increased with decreasing capillary length due to reduced losses to the inside walls of the capillary. This increase in transmission efficiency with shorter inlets was coupled with reduced desolvation of electrosprayed droplets. Surprisingly, as the inlet length was decreased, some analytes showed little or no increase in sensitivity, while others showed as much as a 15-fold gain. The variation was shown to be at least partially correlated with analyte mobilities, with the largest gains observed for higher mobility species, but also affected by solution conductivity, flow rate, and inlet temperature. Strategies for maximizing sensitivity while minimizing biases in ion transmission through the heated capillary interface are proposed. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 1% |
| Unknown | 89 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 27% |
| Researcher | 16 | 18% |
| Student > Master | 11 | 12% |
| Student > Bachelor | 8 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 10 | 11% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 44 | 49% |
| Agricultural and Biological Sciences | 5 | 6% |
| Physics and Astronomy | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 10 | 11% |
| Unknown | 21 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2020.
All research outputs
#3,823,715
of 25,498,750 outputs
Outputs from Journal of the American Society for Mass Spectrometry
#255
of 3,850 outputs
Outputs of similar age
#18,653
of 177,467 outputs
Outputs of similar age from Journal of the American Society for Mass Spectrometry
#1
of 3 outputs
Altmetric has tracked 25,498,750 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,850 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,467 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them