| Title |
Physical activity mitigates adverse effect of metabolic syndrome on vessels and brain
|
|---|---|
| Published in |
Brain Imaging and Behavior, January 2018
|
| DOI | 10.1007/s11682-018-9830-3 |
| Pubmed ID | |
| Authors |
Evan P. Pasha, Alex C. Birdsill, Stephanie Oleson, Andreana P. Haley, Hirofumi Tanaka |
| Abstract |
Metabolic syndrome (MetS) adversely affects the vasculature and cerebral white matter (CWM) integrity. Arterial stiffening has been associated with diminished CWM integrity. Physical activity (PA) can ameliorate components of MetS and subsequently affect arterial stiffening and CWM integrity. Our aim was to determine the role of PA on mitigating the adverse influence of MetS on arterial stiffness and CWM integrity. In a cross-sectional study design, sixty-six middle-aged adults (40-62 years) composed of 18 sedentary MetS (Sed MetS), 21 physically active MetS (Active MetS), and 27 healthy individuals absent of MetS risk factors were studied. Carotid artery stiffness was assessed via simultaneous ultrasound and tonometry. CWM integrity was measured using diffusion tensor imaging (DTI) through metrics of fractional anisotropy (FA) and mean diffusivity (MD). Carotid β-stiffness index in Active MetS was lower than Sed MetS but was not different from Healthy controls (6.6 ± 1.5, 7.7 ± 2.1, and 5.6 ± 1.6 au, p = 0.001). CWM integrity was significantly greater in Active MetS subjects compared to Sed MetS subjects but statistically equal to Healthy controls in the anterior limb of the internal capsule, and splenium of the corpus callosum, uncinate fasciculus, and superior corona radiata (all p < 0.05). Middle-aged individuals with MetS who habitually perform PA demonstrated lower arterial stiffness and more favorable CWM integrity than their sedentary peers, indicating that PA may be effective in mitigating the adverse effects of MetS on the vasculature and brain at midlife. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 13% |
| Researcher | 9 | 13% |
| Student > Master | 6 | 9% |
| Student > Doctoral Student | 5 | 7% |
| Student > Bachelor | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 28 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 13% |
| Medicine and Dentistry | 9 | 13% |
| Nursing and Health Professions | 8 | 12% |
| Psychology | 2 | 3% |
| Sports and Recreations | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 34 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2018.
All research outputs
#17,927,741
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Outputs from Brain Imaging and Behavior
#811
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Outputs of similar age
#309,715
of 440,582 outputs
Outputs of similar age from Brain Imaging and Behavior
#20
of 37 outputs
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