| Title |
Signal transduction via the stem cell factor receptor/c-Kit
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2004
|
| DOI | 10.1007/s00018-004-4189-6 |
| Pubmed ID | |
| Authors |
L. Rönnstrand |
| Abstract |
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors. Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling. |
Mendeley readers
The data shown below were compiled from readership statistics for 272 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| France | 2 | <1% |
| United States | 2 | <1% |
| Switzerland | 1 | <1% |
| Czechia | 1 | <1% |
| Singapore | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Luxembourg | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 260 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 21% |
| Researcher | 51 | 19% |
| Student > Master | 39 | 14% |
| Student > Bachelor | 29 | 11% |
| Student > Doctoral Student | 16 | 6% |
| Other | 39 | 14% |
| Unknown | 41 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 99 | 36% |
| Biochemistry, Genetics and Molecular Biology | 58 | 21% |
| Medicine and Dentistry | 34 | 13% |
| Immunology and Microbiology | 10 | 4% |
| Chemistry | 7 | 3% |
| Other | 15 | 6% |
| Unknown | 49 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2023.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#10,358
of 62,443 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 23 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.