| Title |
Effect of escitalopram and carbidopa on bone markers in Wistar rats: a preliminary experimental study
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, January 2018
|
| DOI | 10.1007/s00774-018-0908-1 |
| Pubmed ID | |
| Authors |
Ravisha Wadhwa, Manoj Kumar, Yam Nath Paudel, Ramsha Iqbal, Priyanka Kothari, Ritu Trivedi, Divya Vohora |
| Abstract |
In view of the opposite effects of gut and brain serotonin in bone, the key role of Wnt β/catenin pathway in osteoblastic proliferation and the controversial bony effects of selective serotonin reuptake inhibitors antidepressants, the present study investigated the effects of escitalopram alone and in combination with carbidopa (to block gut-derived serotonin) on markers of bone turnover and Wnt signaling and micro-CT in male Wistar rats. Escitalopram (2.0 mg/kg, p.o.) and carbidopa (10 mg/kg, p.o.) were administered daily for 40 days following which indicators of reduced (dickkopf-1, sclerostin), and increased (alkaline phosphatase) bone formation and bone resorption markers (receptor activator of nuclear factor κB ligand, tartrate-resistant acid phosphatase 5b) were determined. Our results indicated that escitalopram adversely affected bone as indicated by reduced bone formation and enhanced bone resorption. Further, the effects of escitalopram on bone formation were possibly mediated through gut serotonin while the mechanisms responsible for effects on resorption seem unrelated to gut serotonin. The promising effects of carbidopa on bone formation, as observed in our study, open up exciting possibilities for this drug requiring further investigations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 13% |
| Other | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Professor | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 3 | 19% |
| Unknown | 7 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Unknown | 9 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2018.
All research outputs
#21,180,380
of 23,842,189 outputs
Outputs from Journal of Bone and Mineral Metabolism
#563
of 787 outputs
Outputs of similar age
#383,066
of 445,614 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#8
of 9 outputs
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