| Title |
Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes
|
|---|---|
| Published in |
Cell and Tissue Research, June 2008
|
| DOI | 10.1007/s00441-008-0627-3 |
| Pubmed ID | |
| Authors |
Isabella Spiwoks-Becker, Christian Maus, Susanne tom Dieck, Anna Fejtová, Lydia Engel, Tanja Wolloscheck, Uwe Wolfrum, Lutz Vollrath, Rainer Spessert |
| Abstract |
Synaptic ribbons (SRs) are prominent organelles that are abundant in the ribbon synapses of sensory neurons where they represent a specialization of the cytomatrix at the active zone (CAZ). SRs occur not only in neurons, but also in neuroendocrine pinealocytes where their function is still obscure. In this study, we report that pinealocyte SRs are associated with CAZ proteins such as Bassoon, Piccolo, CtBP1, Munc13-1, and the motorprotein KIF3A and, therefore, consist of a protein complex that resembles the ribbon complex of retinal and other sensory ribbon synapses. The pinealocyte ribbon complex is biochemically dynamic. Its protein composition changes in favor of Bassoon, Piccolo, and Munc13-1 at night and in favor of KIF3A during the day, whereas CtBP1 is equally present during the night and day. The diurnal dynamics of the ribbon complex persist under constant darkness and decrease after stimulus deprivation of the pineal gland by constant light. Our findings indicate that neuroendocrine pinealocytes possess a protein complex that resembles the CAZ of ribbon synapses in sensory organs and whose dynamics are under circadian regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 30% |
| Professor > Associate Professor | 4 | 12% |
| Student > Master | 4 | 12% |
| Student > Ph. D. Student | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 8 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 45% |
| Neuroscience | 5 | 15% |
| Medicine and Dentistry | 3 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Veterinary Science and Veterinary Medicine | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 8 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2022.
All research outputs
#7,862,539
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#527
of 2,279 outputs
Outputs of similar age
#29,468
of 83,944 outputs
Outputs of similar age from Cell and Tissue Research
#3
of 7 outputs
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