Title |
Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine
|
---|---|
Published in |
Biomedical Materials, January 2018
|
DOI | 10.1088/1748-605x/aa9486 |
Pubmed ID | |
Authors |
Marian Fürsatz, Mårten Skog, Petter Sivlér, Eleonor Palm, Christopher Aronsson, Andreas Skallberg, Grzegorz Greczynski, Hazem Khalaf, Torbjörn Bengtsson, Daniel Aili |
Abstract |
Wound dressings based on bacterial cellulose (BC) can form a soft and conformable protective layer that can stimulate wound healing while preventing bacteria from entering the wound. Bacteria already present in the wound can, however, thrive in the moist environment created by the BC dressing which can aggravate the healing process. Possibilities to render the BC antimicrobial without affecting the beneficial structural and mechanical properties of the material would hence be highly attractive. Here we present methods for functionalization of BC with ε-Poly-L-Lysine (ε-PLL), a non-toxic biopolymer with broad-spectrum antimicrobial activity. Low molecular weight ε-PLL was cross-linked in pristine BC membranes and to carboxymethyl cellulose (CMC) functionalized BC using carbodiimide chemistry. The functionalization of BC with ε-PLL inhibited growth of S. epidermidis on the membranes but did not affect the cytocompatibility to cultured human fibroblasts as compared to native BC. The functionalization had no significant effects on the nanofibrous structure and mechanical properties of the BC. The possibility to functionalize BC with ε-PLL is a promising, green and versatile approach to improve the performance of BC in wound care and other biomedical applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 143 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 16% |
Student > Master | 21 | 15% |
Student > Bachelor | 14 | 10% |
Researcher | 12 | 8% |
Student > Doctoral Student | 7 | 5% |
Other | 18 | 13% |
Unknown | 48 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 14% |
Engineering | 13 | 9% |
Chemistry | 13 | 9% |
Materials Science | 11 | 8% |
Agricultural and Biological Sciences | 7 | 5% |
Other | 18 | 13% |
Unknown | 61 | 43% |