| Title |
Involvement of autophagy in viral infections: antiviral function and subversion by viruses
|
|---|---|
| Published in |
Journal of Molecular Medicine, March 2007
|
| DOI | 10.1007/s00109-007-0173-6 |
| Pubmed ID | |
| Authors |
Lucile Espert, Patrice Codogno, Martine Biard-Piechaczyk |
| Abstract |
Autophagy is a cellular process involved in the degradation and turn-over of long-lived proteins and organelles, which can be subjected to suppression or further induction in response to different stimuli. According to its essential role in cellular homeostasis, autophagy has been implicated in several pathologies including cancer, neurodegeneration and myopathies. More recently, autophagy has been described as a mechanism of both innate and adaptive immunity against intracellular bacteria and viruses. In this context, autophagy has been proposed as a protective mechanism against viral infection by degrading the pathogens into autolysosomes. This is strengthened by the fact that several proteins involved in interferon (IFN) signalling pathways are linked to autophagy regulation. However, several viruses have evolved strategies to divert IFN-mediated pathways and autophagy to their own benefit. This review provides an overview of the autophagic process and its involvement in the infection by different viral pathogens and of the connections existing between autophagy and proteins involved in IFN signalling pathways. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| United States | 2 | 4% |
| Brazil | 1 | 2% |
| Germany | 1 | 2% |
| China | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 49 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 28% |
| Researcher | 13 | 23% |
| Student > Master | 7 | 12% |
| Professor | 3 | 5% |
| Student > Postgraduate | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 5 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 58% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Immunology and Microbiology | 5 | 9% |
| Computer Science | 2 | 4% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 6 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2016.
All research outputs
#5,736,984
of 22,783,848 outputs
Outputs from Journal of Molecular Medicine
#382
of 1,550 outputs
Outputs of similar age
#22,788
of 76,191 outputs
Outputs of similar age from Journal of Molecular Medicine
#11
of 18 outputs
Altmetric has tracked 22,783,848 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,191 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.