| Title |
Base Composition Skews, Replication Orientation, and Gene Orientation in 12 Prokaryote Genomes
|
|---|---|
| Published in |
Journal of Molecular Evolution, December 1998
|
| DOI | 10.1007/pl00006428 |
| Pubmed ID | |
| Authors |
Michael J. McLean, Kenneth H. Wolfe, Kevin M. Devine |
| Abstract |
Variation in GC content, GC skew and AT skew along genomic regions was examined at third codon positions in completely sequenced prokaryotes. Eight out of nine eubacteria studied show GC and AT skews that change sign at the origin of replication. The leading strand in DNA replication is G-T rich at codon position 3 in six eubacteria, but C-T rich in two Mycoplasma species. In M. genitalium the AT and GC skews are symmetrical around the origin and terminus of replication, whereas its GC content variation has been shown to have a centre of symmetry elsewhere in the genome. Borrelia burgdorferi and Treponema pallidum show extraordinary extents of base composition skew correlated with direction of DNA replication. Base composition skews measured at third codon positions probably reflect mutational biases, whereas those measured over all bases in a sequence (or at codon positions 1 and 2) can be strongly affected by protein considerations due to the tendency in some bacteria for genes to be transcribed in the same direction that they are replicated. Consequently in some species the direction of skew for total genomic DNA is opposite to that for codon position 3. |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| Germany | 3 | 2% |
| United Kingdom | 2 | 2% |
| India | 2 | 2% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Israel | 1 | <1% |
| Brazil | 1 | <1% |
| Argentina | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 108 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 31% |
| Student > Ph. D. Student | 32 | 25% |
| Student > Master | 10 | 8% |
| Professor | 9 | 7% |
| Student > Bachelor | 8 | 6% |
| Other | 19 | 15% |
| Unknown | 9 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 76 | 60% |
| Biochemistry, Genetics and Molecular Biology | 28 | 22% |
| Computer Science | 5 | 4% |
| Physics and Astronomy | 2 | 2% |
| Business, Management and Accounting | 1 | <1% |
| Other | 5 | 4% |
| Unknown | 10 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2015.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Journal of Molecular Evolution
#492
of 1,477 outputs
Outputs of similar age
#24,477
of 109,562 outputs
Outputs of similar age from Journal of Molecular Evolution
#5
of 17 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,477 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.