| Title |
Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, September 2000
|
| DOI | 10.1007/s002590000365 |
| Pubmed ID | |
| Authors |
S. Houle, N. Ginovart, D. Hussey, J.H. Meyer, A.A. Wilson |
| Abstract |
Two novel radioligands, N,N-dimethyl-2-(2-amino-4-methoxyphenylthio) b enzylamine (DAPP) and (N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine (D ASB), were radiolabeled with carbon-11 and evaluated as in vivo probes of the serotonin transporter (SERT) using positron emission tomography (PET). Both compounds are highly selective, with nanomolar affinity for the serotonin transporter and micromolar affinity for the dopamine and norepinephrine transporters. Six volunteers were imaged twice, once with each of the two radioligands. Both ligands displayed very good brain penetration and selective retention in regions rich in serotonin reuptake sites. Both had similar brain uptake and kinetics, but the cyano analogue, [11C]DASB, had a slightly higher brain penetration in all subjects. Plasma analysis revealed that both radiotracers were rapidly metabolized to give mainly hydrophilic species as determined by reverse-phase high-performance liquid chromatography. Inhibition of specific binding to the SERT was demonstrated in three additional subjects imaged with [11C]DASB following an oral dose of the selective serotonin reuptake blocker citalopram. These preliminary studies indicate that both these substituted phenylthiobenzylamines have highly suitable characteristics for probing the serotonin reuptake system with PET in humans. |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Italy | 1 | 1% |
| Denmark | 1 | 1% |
| Spain | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 76 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 24% |
| Student > Ph. D. Student | 16 | 20% |
| Professor > Associate Professor | 11 | 13% |
| Student > Bachelor | 10 | 12% |
| Student > Master | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 28% |
| Chemistry | 11 | 13% |
| Psychology | 8 | 10% |
| Agricultural and Biological Sciences | 7 | 9% |
| Neuroscience | 7 | 9% |
| Other | 9 | 11% |
| Unknown | 17 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2018.
All research outputs
#3,873,876
of 25,837,817 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#433
of 3,565 outputs
Outputs of similar age
#3,655
of 38,460 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#1
of 14 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,565 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 38,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.