| Title |
Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity – a [11C]DASB PET study
|
|---|---|
| Published in |
Journal of Neural Transmission, August 2007
|
| DOI | 10.1007/s00702-007-0785-6 |
| Pubmed ID | |
| Authors |
M. Reimold, M. N. Smolka, A. Zimmer, A. Batra, A. Knobel, C. Solbach, A. Mundt, H. U. Smoltczyk, D. Goldman, K. Mann, G. Reischl, H.-J. Machulla, R. Bares, A. Heinz |
| Abstract |
Reduced availability of brainstem serotonin transporters (5-HTT) has been observed in vivo in obsessive-compulsive disorder (OCD). However, results vary and may be influenced by competition with endogenous serotonin. Using positron emission tomography (PET) and [11C]DASB, a specific 5-HTT ligand that showed no competition with serotonin for 5-HTT binding in vitro, we tested the hypothesis that 5-HTT availability is reduced in OCD patients and correlated with OCD severity. METHODS. 5-HTT availability in the thalamus and the midbrain was measured in nine drug-free OCD patients and compared with 19 healthy controls, matched for the individual combination of 5-HTT genotype, gender and smoking status. OCD severity was assessed with the Yale-Brown obsessive compulsive scale (Y-BOCS). RESULTS. 5-HTT availability was significantly reduced in the thalamus and midbrain of OCD patients. Age and 5-HTT in the thalamus explained 83% of OCD severity in patients that were drug-free for at least 1 year. CONCLUSION. This PET study confirms a central role of the serotonergic system, particularly the thalamus in the pathogenesis of obsessive compulsive disorder. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Germany | 1 | 2% |
| Austria | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 47 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 7 | 14% |
| Student > Master | 7 | 14% |
| Student > Doctoral Student | 7 | 14% |
| Researcher | 6 | 12% |
| Student > Ph. D. Student | 4 | 8% |
| Other | 9 | 18% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 27% |
| Psychology | 7 | 14% |
| Agricultural and Biological Sciences | 5 | 10% |
| Neuroscience | 4 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2012.
All research outputs
#7,452,489
of 22,783,848 outputs
Outputs from Journal of Neural Transmission
#630
of 1,764 outputs
Outputs of similar age
#24,551
of 67,836 outputs
Outputs of similar age from Journal of Neural Transmission
#5
of 10 outputs
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