| Title |
Interaction between Wiskott–Aldrich Syndrome Protein (WASP) and the Fyn protein-tyrosine kinase
|
|---|---|
| Published in |
Molecular Biology Reports, August 1999
|
| DOI | 10.1023/a:1006954206151 |
| Pubmed ID | |
| Authors |
Sharon Banin, Ivan Gout, Paul Brickell |
| Abstract |
Wiskott-Aldrich Syndrome (WAS) is a severe X-linked disorder characterised by immune deficiency, thrombocytopenia and eczema, resulting from abnormalities in a range of haematopoietic cell types. The protein that is defective in WAS, named WASP, appears to be involved in regulating changes in the cytoskeletal organisation of haematopoietic cells in response to external stimuli. In support of this idea, WASP has been found to be physically associated in haematopoietic cells in vivo with a number of SH3 domain-containing proteins involved in signal transduction, including the cytoplasmic protein-tyrosine kinase Fyn. Here, we have used a baculovirus expression system to explore the biochemical consequences of the interaction between WASP and Fyn. We find that the kinase activity of Fyn is stimulated as a result of binding to WASP, and that a cellular protein, which may be WASP itself, becomes phosphorylated on tyrosine as a result of the binding of WASP to Fyn. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 23% |
| Student > Ph. D. Student | 3 | 23% |
| Student > Bachelor | 2 | 15% |
| Professor | 2 | 15% |
| Student > Doctoral Student | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 38% |
| Biochemistry, Genetics and Molecular Biology | 3 | 23% |
| Chemistry | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Unknown | 3 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2023.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Molecular Biology Reports
#490
of 3,319 outputs
Outputs of similar age
#11,275
of 34,663 outputs
Outputs of similar age from Molecular Biology Reports
#1
of 2 outputs
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So far Altmetric has tracked 3,319 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
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