| Title |
Lipoprotein lipase: structure, function, regulation, and role in disease
|
|---|---|
| Published in |
Journal of Molecular Medicine, October 2002
|
| DOI | 10.1007/s00109-002-0384-9 |
| Pubmed ID | |
| Authors |
James R. Mead, Scott A. Irvine, Dipak P. Ramji |
| Abstract |
Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation. Research carried out over the past two decades have not only established a central role for LPL in the overall lipid metabolism and transport but have also identified additional, non-catalytic functions of the enzyme. Furthermore, abnormalities in LPL function have been found to be associated with a number of pathophysiological conditions, including atherosclerosis, chylomicronaemia, obesity, Alzheimer's disease, and dyslipidaemia associated with diabetes, insulin resistance, and infection. Advances have also been made in relating the various domains in the protein to different functions, and in understanding the mechanisms that are responsible for the changes in LPL expression seen in response to nutritional and other physiological changes, and during disease. This review summarises recent findings in relation to the structure, function, and regulation of LPL along with its important role in disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Georgia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 586 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 3 | <1% |
| Brazil | 1 | <1% |
| Uruguay | 1 | <1% |
| Germany | 1 | <1% |
| Egypt | 1 | <1% |
| Canada | 1 | <1% |
| Russia | 1 | <1% |
| Luxembourg | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 572 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 126 | 22% |
| Student > Master | 98 | 17% |
| Student > Bachelor | 84 | 14% |
| Researcher | 51 | 9% |
| Student > Doctoral Student | 34 | 6% |
| Other | 78 | 13% |
| Unknown | 115 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 148 | 25% |
| Biochemistry, Genetics and Molecular Biology | 111 | 19% |
| Medicine and Dentistry | 86 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 3% |
| Chemistry | 16 | 3% |
| Other | 63 | 11% |
| Unknown | 143 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2023.
All research outputs
#2,652,263
of 26,017,215 outputs
Outputs from Journal of Molecular Medicine
#85
of 2,176 outputs
Outputs of similar age
#3,160
of 52,610 outputs
Outputs of similar age from Journal of Molecular Medicine
#2
of 9 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,176 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 52,610 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.