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BRCA1 Circos: a visualisation resource for functional analysis of missense variants

Overview of attention for article published in Journal of Medical Genetics, February 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

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1 blog
twitter
2 X users
facebook
2 Facebook pages

Citations

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31 Dimensions

Readers on

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76 Mendeley
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Title
BRCA1 Circos: a visualisation resource for functional analysis of missense variants
Published in
Journal of Medical Genetics, February 2015
DOI 10.1136/jmedgenet-2014-102766
Pubmed ID
Authors

Ankita Jhuraney, Aneliya Velkova, Randall C Johnson, Bailey Kessing, Renato S Carvalho, Phillip Whiley, Amanda B Spurdle, Maaike P G Vreeswijk, Sandrine M Caputo, Gael A Millot, Ana Vega, Nicolas Coquelle, Alvaro Galli, Diana Eccles, Marinus J Blok, Tuya Pal, Rob B van der Luijt, Marta Santamariña Pena, Susan L Neuhausen, Talia Donenberg, Eva Machackova, Simon Thomas, Maxime Vallée, Fergus J Couch, Sean V Tavtigian, J N Mark Glover, Marcelo A Carvalho, Lawrence C Brody, Shyam K Sharan, Alvaro N Monteiro

Abstract

Inactivating germline mutations in the tumour suppressor gene BRCA1 are associated with a significantly increased risk of developing breast and ovarian cancer. A large number (>1500) of unique BRCA1 variants have been identified in the population and can be classified as pathogenic, non-pathogenic or as variants of unknown significance (VUS). Many VUS are rare missense variants leading to single amino acid changes. Their impact on protein function cannot be directly inferred from sequence information, precluding assessment of their pathogenicity. Thus, functional assays are critical to assess the impact of these VUS on protein activity. BRCA1 is a multifunctional protein and different assays have been used to assess the impact of variants on different biochemical activities and biological processes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 14%
Student > Ph. D. Student 9 12%
Student > Doctoral Student 9 12%
Other 8 11%
Researcher 7 9%
Other 16 21%
Unknown 16 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 25%
Agricultural and Biological Sciences 16 21%
Medicine and Dentistry 13 17%
Computer Science 2 3%
Nursing and Health Professions 1 1%
Other 6 8%
Unknown 19 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2017.
All research outputs
#3,620,878
of 22,783,848 outputs
Outputs from Journal of Medical Genetics
#665
of 2,917 outputs
Outputs of similar age
#52,725
of 351,943 outputs
Outputs of similar age from Journal of Medical Genetics
#12
of 35 outputs
Altmetric has tracked 22,783,848 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,917 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,943 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.