| Title |
NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
|
|---|---|
| Published in |
Acta Neuropathologica, October 1998
|
| DOI | 10.1007/s004010050917 |
| Pubmed ID | |
| Authors |
K. Arima, Kenji Uéda, Nobuhiko Sunohara, Kenji Arakawa, Shigeo Hirai, Minako Nakamura, Haruko Tonozuka-Uehara, Mitsuru Kawai |
| Abstract |
We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid beta component of Alzheimer's disease amyloid precursor protein (NACP/alpha-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Costa Rica | 1 | 1% |
| Panama | 1 | 1% |
| Unknown | 71 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 27% |
| Researcher | 11 | 15% |
| Student > Master | 7 | 10% |
| Professor | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Other | 14 | 19% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 22% |
| Medicine and Dentistry | 15 | 21% |
| Neuroscience | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Chemistry | 3 | 4% |
| Other | 2 | 3% |
| Unknown | 14 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2024.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Acta Neuropathologica
#1,519
of 2,527 outputs
Outputs of similar age
#10,232
of 32,087 outputs
Outputs of similar age from Acta Neuropathologica
#3
of 12 outputs
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