| Title |
Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood
|
|---|---|
| Published in |
Journal of Neurology, December 2017
|
| DOI | 10.1007/s00415-017-8719-1 |
| Pubmed ID | |
| Authors |
Maria Åberg, Jenny Nyberg, Josefina Robertson, Georg Kuhn, Linus Schiöler, Hans Nissbrandt, Margda Waern, Kjell Torén |
| Abstract |
Recent research suggests that the incidence of amyotrophic lateral sclerosis (ALS) may be on the rise. Since ALS becomes predominant in later life, most studies on causal factors are conducted in middle-aged or older populations where potentially important influences from early life can usually not be adequately captured. We aimed to investigate predictors in young Swedish men for ALS in adulthood. Therefore, we performed a prospective cohort study of young men (aged 16-25, n = 1,819,817) who enlisted 1968-2005 and took part in comprehensive conscription examinations. Incident cases of ALS (n = 526) during up to 46 years of follow-up were identified in the National Hospital Register and Swedish Cause of Death Register. Those who developed ALS had lower BMI (body mass index) at conscription than their peers (p = 0.03). The risk of ALS during follow-up was calculated with Cox proportional hazards models. No associations were found with physical fitness, erythrocyte sedimentation rate, or non-psychotic mental disorders. Low overall muscle strength compared to high overall muscle strength [hazard ratio (HR) 1.36; 95% confidence interval (CI) 1.01-1.83] and low BMI (a one-unit increase HR 0.96; 95% CI 0.93-0.99) and lower erythrocyte volume fraction (a one-unit increase HR 0.96; 95% CI 0.92-0.998) were the statistically significant predictors for ALS in adjusted models. These findings provide novel epidemiologic evidence of a prospective association between low overall muscle strength and erythrocyte volume fraction in young men and ALS risk. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 20% |
| United Kingdom | 2 | 20% |
| Australia | 1 | 10% |
| France | 1 | 10% |
| Sweden | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 18% |
| Student > Ph. D. Student | 8 | 13% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 4 | 6% |
| Student > Master | 3 | 5% |
| Other | 4 | 6% |
| Unknown | 27 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 23% |
| Nursing and Health Professions | 5 | 8% |
| Psychology | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Sports and Recreations | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 31 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 117. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2018.
All research outputs
#304,017
of 23,020,670 outputs
Outputs from Journal of Neurology
#31
of 4,523 outputs
Outputs of similar age
#7,778
of 441,975 outputs
Outputs of similar age from Journal of Neurology
#1
of 84 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,523 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.