| Title |
Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit
|
|---|---|
| Published in |
Experimental Brain Research, January 2018
|
| DOI | 10.1007/s00221-018-5187-5 |
| Pubmed ID | |
| Authors |
Amrita Benoy, Ananya Dasgupta, Sreedharan Sajikumar |
| Abstract |
The hippocampus is a critical brain region for the formation of declarative memories. While social memory had long been attributed to be a function of the hippocampus, it is only of late that the area CA2 of the hippocampus was demarcated as essential for social memory formation. In addition to this distinct role, CA2 possesses unique molecular, structural and physiological characteristics compared to the other CA regions-CA1 and CA3, and the dentate gyrus (DG). CA2 pyramidal neurons are positioned at a location between CA1 and CA3, receiving inputs from CA3 and DG, in addition to forming a powerful disynaptic circuit with direct input from the entorhinal cortical layer II neurons. CA2 also receives direct inputs from the hypothalamic regions and displays a unique expression pattern for receptors for neuromodulators. The location, inputs, and molecular signatures of the area CA2 point to the possibility that CA2 serves as a modulatory gateway that processes information from the entorhinal cortex and CA3, before relaying them onto CA1, the major output of the hippocampus. This review discusses recent findings regarding plasticity and neuromodulation in the CA2 region of the hippocampus, and how this may have the potential to influence plasticity in connecting circuits, and thereby memory and behaviour. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 23% |
| Student > Master | 13 | 13% |
| Student > Bachelor | 12 | 12% |
| Researcher | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 9 | 9% |
| Unknown | 27 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 39% |
| Agricultural and Biological Sciences | 13 | 13% |
| Medicine and Dentistry | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Engineering | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 31 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2022.
All research outputs
#14,140,645
of 23,103,436 outputs
Outputs from Experimental Brain Research
#1,730
of 3,251 outputs
Outputs of similar age
#232,822
of 440,572 outputs
Outputs of similar age from Experimental Brain Research
#23
of 48 outputs
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