| Title |
Mammalian histone acetyltransferases and their complexes
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2001
|
| DOI | 10.1007/pl00000892 |
| Pubmed ID | |
| Authors |
V.V. Ogryzko |
| Abstract |
One of the key questions in the current molecular genetics of eukaryotes is how genetic information is retrieved from tightly packed chromatin. Acetylation of core histone N-termini is implicated in the regulation of chromatin function, and I summarize what is known about the mammalian enzymes that promote this posttranslational histone modification. Chromatin is important in gene expression not only because of the accessibility problem that it poses for the transcriptional machinery but also with regard to the phenomenon of chromatin memory, i.e. the ability of alternative chromatin states to be maintained through many cell divisions. This phenomenon is believed to be central to epigenetic inheritance, an important concept in developmental biology, which is also emerging as a contributing factor in cancer and other health disorders. Analyses of the composition of large multiprotein acetyltransferase complexes suggest their role in the mechanisms of epigenetic inheritance. The review will discuss some models pertinent to this function of histone acetyltransferases. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| United States | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 43% |
| Researcher | 5 | 22% |
| Student > Bachelor | 2 | 9% |
| Other | 1 | 4% |
| Lecturer | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 43% |
| Agricultural and Biological Sciences | 10 | 43% |
| Psychology | 1 | 4% |
| Neuroscience | 1 | 4% |
| Unknown | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2023.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Cellular and Molecular Life Sciences
#2,145
of 5,876 outputs
Outputs of similar age
#14,305
of 42,351 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#9
of 18 outputs
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