| Title |
Recent advances in osteoclast biology
|
|---|---|
| Published in |
Histochemistry and Cell Biology, February 2018
|
| DOI | 10.1007/s00418-018-1636-2 |
| Pubmed ID | |
| Authors |
Takehito Ono, Tomoki Nakashima |
| Abstract |
The bone is an essential organ for locomotion and protection of the body, as well as hematopoiesis and mineral homeostasis. In order to exert these functions throughout life, bone tissue undergoes a repeating cycle of osteoclastic bone resorption and osteoblastic bone formation. The osteoclast is a large, multinucleated cell that is differentiated from monocyte/macrophage lineage cells by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL). RANKL transduces its signal through the signaling receptor, RANK. RANKL/RANK signaling activates NFATc1, the master regulator of osteoclastogenesis, to induce osteoclastogenic gene expression. Many types of cells express RANKL to support osteoclastogenesis depending on the biological context and the dysregulation of RANKL signaling leads to bone diseases such as osteoporosis and osteopetrosis. This review outlines the findings on osteoclast and RANKL/RANK signaling that have accumulated to date. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 232 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 232 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 12% |
| Student > Bachelor | 26 | 11% |
| Student > Master | 21 | 9% |
| Student > Postgraduate | 16 | 7% |
| Researcher | 13 | 6% |
| Other | 35 | 15% |
| Unknown | 94 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 51 | 22% |
| Biochemistry, Genetics and Molecular Biology | 39 | 17% |
| Agricultural and Biological Sciences | 16 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Engineering | 7 | 3% |
| Other | 16 | 7% |
| Unknown | 96 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2019.
All research outputs
#7,521,038
of 24,217,893 outputs
Outputs from Histochemistry and Cell Biology
#222
of 926 outputs
Outputs of similar age
#147,229
of 447,434 outputs
Outputs of similar age from Histochemistry and Cell Biology
#14
of 22 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 926 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 447,434 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.