| Title |
High versus low-dose caffeine for apnea of prematurity: a randomized controlled trial
|
|---|---|
| Published in |
European Journal of Pediatrics, February 2015
|
| DOI | 10.1007/s00431-015-2494-8 |
| Pubmed ID | |
| Authors |
Sameh Mohammed, Islam Nour, Abd Elazeez Shabaan, Basma Shouman, Hesham Abdel-Hady, Nehad Nasef |
| Abstract |
The optimum caffeine dose in preterm infants has not been well investigated. We aimed to compare the efficacy and safety of high versus low-dose caffeine citrate on apnea of prematurity (AOP) and successful extubation of preterm infants from mechanical ventilation. We compared high-dose (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) versus low-dose (loading 20 mg/kg/day and maintenance of 10 mg/kg/day) caffeine citrate in preterm infants <32 weeks gestation, presented with AOP within the first 10 days of life. A total of 120 neonates (60 in each group) were enrolled. High-dose caffeine was associated with a significant reduction in extubation failure in mechanically ventilated preterm infants (p < 0.05), the frequency of apnea (p < 0.001), and days of documented apnea (p < 0.001). High-dose caffeine was associated with significant increase in episodes of tachycardia (p < 0.05) without a significant impact on physician decision to withhold caffeine. Conclusion: The use of higher, than current standard, dose of caffeine may decrease the chance of extubation failure in mechanically ventilated preterm infants and frequency of AOP without significant side effects. What is Known: • Caffeine therapy for treatment of apnea of prematurity has been well established over the past few years. The optimal loading and maintenance dose of caffeine in preterm infants is not well-studied. What is New: • This double blind randomized controlled trial demonstrated that using a higher, than current standard, loading and maintenance doses of caffeine for treatment of apnea in preterm infants is well tolerated and significantly decrease the frequency of apnea. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 250 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Ethiopia | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 247 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 97 | 39% |
| Researcher | 21 | 8% |
| Student > Doctoral Student | 15 | 6% |
| Student > Postgraduate | 14 | 6% |
| Student > Ph. D. Student | 13 | 5% |
| Other | 39 | 16% |
| Unknown | 51 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 89 | 36% |
| Nursing and Health Professions | 27 | 11% |
| Agricultural and Biological Sciences | 27 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 5% |
| Neuroscience | 7 | 3% |
| Other | 28 | 11% |
| Unknown | 60 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2022.
All research outputs
#2,778,018
of 23,299,593 outputs
Outputs from European Journal of Pediatrics
#415
of 3,835 outputs
Outputs of similar age
#41,027
of 354,858 outputs
Outputs of similar age from European Journal of Pediatrics
#3
of 40 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,835 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done well, scoring higher than 88% of its peers.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.