| Title |
Activities of the chaperonin containing TCP-1 (CCT): implications for cell cycle progression and cytoskeletal organisation.
|
|---|---|
| Published in |
Cell Stress and Chaperones, July 2008
|
| DOI | 10.1007/s12192-008-0057-x |
| Pubmed ID | |
| Authors |
Karen I. Brackley, Julie Grantham |
| Abstract |
The chaperonin containing TCP-1 (CCT) is required for the production of native actin and tubulin and numerous other proteins, several of which are involved in cell cycle progression. The mechanistic details of how CCT acts upon its folding substrates are intriguing: whilst actin and tubulin bind in a sequence-specific manner, it is possible that some proteins could use CCT as a more general binding interface. Therefore, how CCT accommodates the folding requirements of its substrates, some of which are produced in a cell cycle-specific manner, is of great interest. The reliance of folding substrates upon CCT for the adoption of their native structures results in CCT activity having far-reaching implications for a vast array of cellular processes. For example, the dependency of the major cytoskeletal proteins actin and tubulin upon CCT results in CCT activity being linked to any cellular process that depends on the integrity of the microfilament and microtubule-based cytoskeletal systems. |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 2 | 2% |
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 110 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 23% |
| Researcher | 25 | 22% |
| Student > Master | 16 | 14% |
| Student > Doctoral Student | 11 | 10% |
| Student > Postgraduate | 7 | 6% |
| Other | 18 | 16% |
| Unknown | 11 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 52% |
| Biochemistry, Genetics and Molecular Biology | 27 | 23% |
| Chemistry | 4 | 3% |
| Neuroscience | 3 | 3% |
| Computer Science | 2 | 2% |
| Other | 8 | 7% |
| Unknown | 11 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2020.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Cell Stress and Chaperones
#203
of 698 outputs
Outputs of similar age
#33,575
of 95,562 outputs
Outputs of similar age from Cell Stress and Chaperones
#2
of 2 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 698 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,562 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.