| Title |
Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, June 1983
|
| DOI | 10.1007/bf00634263 |
| Pubmed ID | |
| Authors |
A. J. Kaumann |
| Abstract |
5-Hydroxytryptamine (5 HT)-induced contractions were investigated on cocaine-treated strips of bovine large coronary arteries. 1. The alpha 2-adrenoceptor blockers rauwolscine and yohimbine antagonized competitively 5 HT-induced contractions. The estimated equilibrium dissociation constants KB (-log mol/l) were 7.1 for rauwolscine and 7.3 for yohimbine. The affinity of yohimbine for the receptors mediating the response to 5 HT appears to be 10 times higher than for postsynaptic alpha 1-adrenoceptors but 10 times lower than for postsynaptic vascular alpha 2-adrenoceptors. 2. (-)-Noradrenaline and the alpha 2-adrenoceptor-selective agonist B-HT 920 caused maximum contractions amounting to only 20% and 2%, respectively, of the maximum 5 HT effects. Neither 60 mumol/l B-HT 920 nor 1 mumol/l prazosin antagonized the 5 HT effect. 3. Ketanserin was a competitive antagonist (KB = 9.2 (-log mol/l] of the effects of 5 HT. Combinations of rauwolscine or yohimbine with ketanserin antagonized the 5 HT effects as expected from competition of the 4 drugs for a single class of receptor. 4. The evidence is consistent with an interaction of 5 HT, ketanserin, rauwolscine and yohimbine with 5 HT2 receptors. alpha-Adrenoceptors only play a minor role in large coronary arteries and appear not to be involved in the 5 HT-induced contractions. A possible clinical involvement of 5 HT in coronary artery spasm is discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 1 | 33% |
| Unknown | 2 | 67% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 1 | 33% |
| Unknown | 2 | 67% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2023.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#438
of 1,892 outputs
Outputs of similar age
#2,312
of 7,997 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#1
of 5 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,892 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 7,997 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them