| Title |
Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse
|
|---|---|
| Published in |
Metabolic Brain Disease, September 2011
|
| DOI | 10.1007/s11011-011-9263-9 |
| Pubmed ID | |
| Authors |
Xin Yan, Jan Lukas, Martin Witt, Andreas Wree, Rayk Hübner, Moritz Frech, Rüdiger Köhling, Arndt Rolfs, Jiankai Luo |
| Abstract |
Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism inducing dysmylination in NPC1 disease is still unclear. In the present study, a quantitative evaluation on the myelin protein and its regulatory factors of oligodendrocytes, such as SRY-related HMG-box 10 (Sox10), Yin Yang 1 factor (YY1) and myelin gene regulatory factor (MRF), in different parts of the brain and spinal cord was performed in NPC1-mutant mice. The results showed that NPC1 protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1-mutant mice. Compared to wild type, the amount of Sox10 and YY1 was not different in NPC1-mutant mice, but MRF was significantly decreased, suggesting a possible mechanism perturbing differentiation of oligodendrocytes and the myelination process in the NPC1-mutant mouse. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Australia | 1 | 2% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Researcher | 10 | 20% |
| Other | 6 | 12% |
| Student > Postgraduate | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Other | 8 | 16% |
| Unknown | 8 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 24% |
| Biochemistry, Genetics and Molecular Biology | 12 | 24% |
| Neuroscience | 5 | 10% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 11 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2012.
All research outputs
#7,452,489
of 22,785,242 outputs
Outputs from Metabolic Brain Disease
#334
of 1,051 outputs
Outputs of similar age
#44,606
of 130,804 outputs
Outputs of similar age from Metabolic Brain Disease
#2
of 4 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,051 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 58% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.