| Title |
Electromagnetic Field Stimulation Potentiates Endogenous Myelin Repair by Recruiting Subventricular Neural Stem Cells in an Experimental Model of White Matter Demyelination
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, May 2012
|
| DOI | 10.1007/s12031-012-9791-8 |
| Pubmed ID | |
| Authors |
Mohammad Amin Sherafat, Motahareh Heibatollahi, Somayeh Mongabadi, Fatemeh Moradi, Mohammad Javan, Abolhassan Ahmadiani |
| Abstract |
Electromagnetic fields (EMFs) may affect the endogenous neural stem cells within the brain. The aim of this study was to assess the effects of EMFs on the process of toxin-induced demyelination and subsequent remyelination. Demyelination was induced using local injection of lysophosphatidylcholine within the corpus callosum of adult female Sprague-Dawley rats. EMFs (60 Hz; 0.7 mT) were applied for 2 h twice a day for 7, 14, or 28 days postlesion. BrdU labeling and immunostaining against nestin, myelin basic protein (MBP), and BrdU were used for assessing the amount of neural stem cells within the tissue, remyelination patterns, and tracing of proliferating cells, respectively. EMFs significantly reduced the extent of demyelinated area and increased the level of MBP staining within the lesion area on days 14 and 28 postlesion. EMFs also increased the number of BrdU- and nestin-positive cells within the area between SVZ and lesion as observed on days 7 and 14 postlesion. It seems that EMF potentiates proliferation and migration of neural stem cells and enhances the repair of myelin in the context of demyelinating conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 66 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 19% |
| Researcher | 8 | 12% |
| Student > Bachelor | 8 | 12% |
| Professor > Associate Professor | 4 | 6% |
| Student > Master | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 20 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 18% |
| Agricultural and Biological Sciences | 10 | 15% |
| Medicine and Dentistry | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Computer Science | 2 | 3% |
| Other | 9 | 13% |
| Unknown | 22 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2017.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Journal of Molecular Neuroscience
#485
of 1,643 outputs
Outputs of similar age
#59,943
of 176,744 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#5
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.