Title |
Type 2 Diabetes and Thiazide Diuretics
|
---|---|
Published in |
Current Diabetes Reports, February 2018
|
DOI | 10.1007/s11892-018-0976-6 |
Pubmed ID | |
Authors |
André J. Scheen |
Abstract |
In patients with prediabetes or type 2 diabetes, the use of thiazides as antihypertensive agents has been challenged because associated metabolic adverse events, including new-onset diabetes. These metabolic disturbances are less marked with low-dose thiazides and, in most but not all studies, with thiazide-like diuretics (chlorthalidone, indapamide) than with thiazide-type diuretics (hydrochlorothiazide). In post hoc analyses of subgroups of patients with hypertension and type 2 diabetes, thiazides resulted in a significant reduction in cardiovascular events, all-cause mortality, and hospitalization for heart failure compared to placebo and generally were shown to be non-inferior to other antihypertensive agents. Benefits attributed to thiazide diuretics in terms of cardiovascular event reduction outweigh the risk of worsening glucose control in type 2 diabetes and of new-onset diabetes in non-diabetic patients. Thiazides still play a key role in the management of patients with type 2 diabetes and hypertension. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 50% |
France | 1 | 25% |
Saudi Arabia | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 108 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 16 | 15% |
Researcher | 10 | 9% |
Student > Ph. D. Student | 8 | 7% |
Student > Doctoral Student | 8 | 7% |
Student > Master | 7 | 6% |
Other | 16 | 15% |
Unknown | 43 | 40% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 6% |
Nursing and Health Professions | 5 | 5% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 4 | 4% |
Unknown | 49 | 45% |