| Title |
Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels
|
|---|---|
| Published in |
Cell Biochemistry and Biophysics, May 2007
|
| DOI | 10.1007/s12013-007-0007-8 |
| Pubmed ID | |
| Authors |
David P. Lotshaw |
| Abstract |
The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15 KCNK genes and subdivided into six subfamilies on the basis of sequence similarities: TWIK, TREK, TASK, TALK, THIK, and TRESK. K2P channels are expressed in cells throughout the body and have been implicated in diverse cellular functions including maintenance of the resting potential and regulation of excitability, sensory transduction, ion transport, and cell volume regulation, as well as metabolic regulation and apoptosis. In recent years K2P channel isoforms have been identified as important targets of several widely employed drugs, including: general anesthetics, local anesthetics, neuroprotectants, and anti-depressants. An important goal of future studies will be to identify the basis of drug actions and channel isoform selectivity. This goal will be facilitated by characterization of native K2P channel isoforms, their pharmacological properties and tissue-specific expression patterns. To this end the present review examines the biophysical, pharmacological, and functional characteristics of cloned mammalian K2P channels and compares this information with the limited data available for native K2P channels in order to determine criteria which may be useful in identifying ionic currents mediated by native channel isoforms and investigating their pharmacological and functional characteristics. |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 117 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 24% |
| Researcher | 25 | 20% |
| Student > Doctoral Student | 13 | 10% |
| Student > Master | 12 | 10% |
| Student > Bachelor | 11 | 9% |
| Other | 20 | 16% |
| Unknown | 14 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 34% |
| Neuroscience | 21 | 17% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Medicine and Dentistry | 9 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
| Other | 15 | 12% |
| Unknown | 16 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2023.
All research outputs
#4,695,422
of 22,785,242 outputs
Outputs from Cell Biochemistry and Biophysics
#51
of 910 outputs
Outputs of similar age
#13,505
of 72,002 outputs
Outputs of similar age from Cell Biochemistry and Biophysics
#1
of 9 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 910 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 72,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them