| Title |
Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme
|
|---|---|
| Published in |
Journal of Neuro-Oncology, December 2006
|
| DOI | 10.1007/s11060-006-9292-0 |
| Pubmed ID | |
| Authors |
Ramon Martinez, Gabriele Schackert, Ricard Yaya-Tur, Iñigo Rojas-Marcos, James G. Herman, Manel Esteller |
| Abstract |
We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Student > Bachelor | 9 | 18% |
| Researcher | 7 | 14% |
| Student > Master | 6 | 12% |
| Student > Doctoral Student | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 37% |
| Biochemistry, Genetics and Molecular Biology | 9 | 18% |
| Medicine and Dentistry | 9 | 18% |
| Neuroscience | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 6 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2012.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Journal of Neuro-Oncology
#1,040
of 2,965 outputs
Outputs of similar age
#41,756
of 156,317 outputs
Outputs of similar age from Journal of Neuro-Oncology
#2
of 13 outputs
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