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Injection of Botulinum Toxin for Preventing Salivary Gland Toxicity after PSMA Radioligand Therapy: an Empirical Proof of a Promising Concept

Overview of attention for article published in Nuclear Medicine and Molecular Imaging, January 2018
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About this Attention Score

  • Among the highest-scoring outputs from this source (#29 of 208)
  • Good Attention Score compared to outputs of the same age (69th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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2 X users
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1 patent

Citations

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68 Dimensions

Readers on

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42 Mendeley
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Title
Injection of Botulinum Toxin for Preventing Salivary Gland Toxicity after PSMA Radioligand Therapy: an Empirical Proof of a Promising Concept
Published in
Nuclear Medicine and Molecular Imaging, January 2018
DOI 10.1007/s13139-017-0508-3
Pubmed ID
Authors

Richard P. Baum, Thomas Langbein, Aviral Singh, Mostafa Shahinfar, Christiane Schuchardt, Gerd Fabian Volk, Harshad Kulkarni

Abstract

The dose-limiting salivary gland toxicity of 225Ac-labelled PSMA for treatment of metastatic, castration-resistant prostate cancer remains unresolved. Suppressing the metabolism of the gland by intraparenchymal injections of botulinum toxin appears to be a promising method to reduce off-target uptake. A 68Ga-PSMA PET/CT scan performed 45 days after injection of 80 units of botulinum toxin A into the right parotid gland in a 63-year-old patient showed a decrease in the SUVmean in the right parotid gland of up to 64% as compared with baseline. This approach could be a significant breakthrough for radioprotection of the salivary glands during PSMA radioligand therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 12%
Student > Bachelor 5 12%
Student > Ph. D. Student 5 12%
Professor 4 10%
Student > Postgraduate 4 10%
Other 10 24%
Unknown 9 21%
Readers by discipline Count As %
Medicine and Dentistry 20 48%
Chemistry 6 14%
Agricultural and Biological Sciences 2 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Arts and Humanities 1 2%
Other 1 2%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2021.
All research outputs
#6,492,028
of 23,020,670 outputs
Outputs from Nuclear Medicine and Molecular Imaging
#29
of 208 outputs
Outputs of similar age
#133,060
of 443,312 outputs
Outputs of similar age from Nuclear Medicine and Molecular Imaging
#1
of 6 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 208 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,312 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them