| Title |
Oligodendrocyte survival in Wallerian degeneration
|
|---|---|
| Published in |
Acta Neuropathologica, June 1990
|
| DOI | 10.1007/bf00308922 |
| Pubmed ID | |
| Authors |
S. K. Ludwin |
| Abstract |
The long-term survival of oligodendrocytes in the absence of axons in adult animals was studied following Wallerian degeneration of the optic nerves of adult rats for periods up to 22 months. In contrast to the findings in development and in young animals, large numbers of oligodendrocytes survived during this time period even when deprived of axonal stimuli. The morphological phenotype of many of these cells differed from those of normal oligodendrocytes, and their oligodendrocytic nature was confirmed at a light microscopic level using antibodies to carbonic anhydrase, and at an electron microscopic level by using antibodies to myelin oligodendrocyte glycoprotein. Although there did appear to be some loss of oligodendrocytes over time, a large proportion appeared to remain intact. Many of the remaining cells and processes appeared to resemble resting or quiescent cells. The survival of these cells demonstrates the differential susceptibility of mature and developing oligodendrocytes to loss of axonal stimulus and also indicates a possible reserve capacity for repair following central nervous system injury. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Unknown | 27 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 32% |
| Student > Bachelor | 5 | 18% |
| Student > Master | 3 | 11% |
| Researcher | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Other | 1 | 4% |
| Unknown | 6 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 36% |
| Neuroscience | 6 | 21% |
| Medicine and Dentistry | 4 | 14% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Unknown | 7 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2020.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Acta Neuropathologica
#1,364
of 2,364 outputs
Outputs of similar age
#4,589
of 16,235 outputs
Outputs of similar age from Acta Neuropathologica
#2
of 6 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,364 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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