| Title |
Chronification of Pain: Mechanisms, Current Understanding, and Clinical Implications
|
|---|---|
| Published in |
Current Pain and Headache Reports, February 2018
|
| DOI | 10.1007/s11916-018-0666-8 |
| Pubmed ID | |
| Authors |
Daniel J. Pak, R. Jason Yong, Alan David Kaye, Richard D. Urman |
| Abstract |
The development of acute to chronic pain involves distinct pathophysiological changes in the peripheral and central nervous systems. This article reviews the mechanisms, etiologies, and management of chronic pain syndromes with updates from recent findings in the literature. Chronic post-surgical pain (CPSP) is not limited to major surgeries and can develop after smaller procedures such as hernia repairs. While nerve injury has traditionally been thought to be the culprit for CPSP, it is evident that nerve-sparing surgical techniques are not completely preventative. Regional analgesia and agents such as ketamine, gabapentinoids, and COX-2 inhibitors have also been found to decrease the risks of developing chronic pain to varying degrees. Yet, given the correlation of central sensitization with the development of chronic pain, it is reasonable to utilize aggressive multimodal analgesia whenever possible. Development of chronic pain is typically a result of peripheral and central sensitization, with CPSP being one of the most common presentations. Using minimally invasive surgical techniques may reduce the risk of CPSP. Regional anesthetic techniques and preemptive analgesia should also be utilized when appropriate to reduce the intensity and duration of acute post-operative pain, which has been correlated with higher incidences of chronic pain. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 19% |
| Italy | 3 | 11% |
| United Kingdom | 1 | 4% |
| Brazil | 1 | 4% |
| Austria | 1 | 4% |
| Germany | 1 | 4% |
| Australia | 1 | 4% |
| Unknown | 14 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 81% |
| Scientists | 4 | 15% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 286 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 286 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 38 | 13% |
| Student > Bachelor | 37 | 13% |
| Other | 27 | 9% |
| Student > Ph. D. Student | 25 | 9% |
| Researcher | 20 | 7% |
| Other | 51 | 18% |
| Unknown | 88 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 86 | 30% |
| Nursing and Health Professions | 28 | 10% |
| Neuroscience | 20 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 5% |
| Psychology | 9 | 3% |
| Other | 35 | 12% |
| Unknown | 95 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2022.
All research outputs
#2,496,884
of 25,199,971 outputs
Outputs from Current Pain and Headache Reports
#133
of 870 outputs
Outputs of similar age
#56,008
of 449,247 outputs
Outputs of similar age from Current Pain and Headache Reports
#6
of 23 outputs
Altmetric has tracked 25,199,971 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 870 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,247 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.