Title |
Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives
|
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Published in |
Psychopharmacologia, January 1975
|
DOI | 10.1007/bf00421005 |
Pubmed ID | |
Authors |
Yoichi Nakazawa, Makoto Kotorii, Masachika Ohshima, Shuichi Horikawa, Hisayuki Tachibana |
Abstract |
The effects of new thienodiazepine derivatives, such as clotiazepam and Y-7131, on normal human sleep were investigated on 5 subjects and compared to those of benzodiazepine derivatives, such as diazepam and nitrazepam. REM sleep was significantly decreased only with 2 mg of Y-7131 and rebound elevation of REM sleep did not follow in recovery 1 and 2 nights. By using partial differential REM deprivation which was designed by us, there was also no rebound elevation of REM sleep noted in recovery 2 nights following 2 mg of Y-7131 medication. REM sleep was not suppressed with 15 mg of clotiazepam, 6 mg of diazepam and 10 mg of nitrazepam when compared to the baseline night. With regard to NREM sleep, stage 2 was significantly increased with 15 mg of clotiazepam and 10 mg of nitrazepam, but stage SWS was significantly decreased with 10 mg of nitrazepam. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 29% |
Unspecified | 3 | 18% |
Professor > Associate Professor | 2 | 12% |
Student > Ph. D. Student | 1 | 6% |
Professor | 1 | 6% |
Other | 2 | 12% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 24% |
Unspecified | 3 | 18% |
Neuroscience | 3 | 18% |
Psychology | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 2 | 12% |
Unknown | 3 | 18% |