| Title |
Arginine pathways and the inflammatory response: Interregulation of nitric oxide and polyamines: Review article
|
|---|---|
| Published in |
Amino Acids, April 2004
|
| DOI | 10.1007/s00726-004-0078-4 |
| Pubmed ID | |
| Authors |
J. Satriano |
| Abstract |
An early response to an acute inflammatory insult, such as wound healing or experimental glomerulonephritis, is the conversion of arginine to the cytostatic molecule nitric oxide (NO). This 'anti-bacterial' phase is followed by the conversion of arginine to ornithine, which is the precursor for the pro-proliferative polyamines as well as proline for the production of extracellular matrix. This latter, pro-growth phase constitutes a 'repair' phase response. The temporal switch of arginine as a substrate for the cytostatic iNOS/NO axis to the pro-growth arginase/ ornithine/polyamine and proline axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves. Arginine is also the precursor for another biogenic amine, agmatine. Here we describe the capacity of these three arginine pathways to interregulate, and propose a model whereby agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in the inflammatory response by acting as a gating mechanism at the transition from the iNOS/NO axis to the arginase/ODC/polyamine axis. Due to the pathophysiologic and therapeutic potential, we will further examine the antiproliferative effects of agmatine on the polyamine pathway. |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Netherlands | 1 | <1% |
| Chile | 1 | <1% |
| Colombia | 1 | <1% |
| United Kingdom | 1 | <1% |
| South Africa | 1 | <1% |
| Greece | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 140 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 17% |
| Researcher | 21 | 14% |
| Student > Master | 20 | 13% |
| Student > Doctoral Student | 13 | 9% |
| Student > Bachelor | 11 | 7% |
| Other | 29 | 19% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 28% |
| Medicine and Dentistry | 23 | 15% |
| Biochemistry, Genetics and Molecular Biology | 21 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
| Chemistry | 8 | 5% |
| Other | 13 | 9% |
| Unknown | 33 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2023.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Amino Acids
#495
of 1,517 outputs
Outputs of similar age
#18,956
of 57,912 outputs
Outputs of similar age from Amino Acids
#5
of 8 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,517 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,912 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.