| Title |
Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled sitespecific delivery of acidic anti-inflammatory active ingredient
|
|---|---|
| Published in |
AAPS PharmSciTech, October 2005
|
| DOI | 10.1208/pt060367 |
| Pubmed ID | |
| Authors |
Abhay Asthana, Abhay Singh Chauhan, Prakash Vamanrao Diwan, Narendra Kumar Jain |
| Abstract |
The purpose of the investigation was to evaluate the potential of polyamidoamine (PAMAM) dendrimer as nanoscale drug delivery units for controlled release of water insoluble and acidic anti-inflammatory drug. Flurbiprofen (FB) was selected as a model acidic anti-inflammatory drug. The aqueous solutions of 4.0 generation (G) PAMAM dendrimer in different concentrations were prepared and used further for solubilizing FB. Formation of dendrimer complex was characterized by Fourier transform infrared spectroscopy. The effect of pH on the solubility of FB in dendrimer was evaluated. Dendrimer formulations were further evaluated for in vitro release study and hemolytic toxicity. Pharmacokinetic and biodistribution were studied in male albino rats. Efficacy of dendrimer formulation was tested by carrageenan induced paw edema model. It was observed that the loaded drug displayed initial rapid release (more than 40% till 3rd hour) followed by rather slow release. Pharmacodynamic study revealed 75% inhibition at 4th hour that was maintained above 50% till 8th hour. The mean residence time (MRT) and terminal half-life (THF) of the dendritic formulation increased by 2-fold and 3-fold, respectively, compared with free drug. Hence, with dendritic system the drug is retained for longer duration in the biosystem with 5-fold greater distribution. It may be concluded that the drug-loaded dendrimers not only enhanced the solubility but also controlled the delivery of the bioactive with localized action at the site of inflammation. |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 19% |
| Student > Master | 13 | 12% |
| Researcher | 11 | 10% |
| Student > Bachelor | 11 | 10% |
| Student > Doctoral Student | 9 | 8% |
| Other | 17 | 15% |
| Unknown | 31 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 19 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 11% |
| Agricultural and Biological Sciences | 11 | 10% |
| Medicine and Dentistry | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Other | 22 | 19% |
| Unknown | 34 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2022.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from AAPS PharmSciTech
#502
of 1,588 outputs
Outputs of similar age
#26,490
of 75,088 outputs
Outputs of similar age from AAPS PharmSciTech
#10
of 26 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,588 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,088 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.